A patient with sarcoidosis presenting with acute renal failure: Implication for granulomatous interstitial nephritis and hypercalcemia

Naro Ohashi; Katsuhiko Yonemura; Manae Hirano; Satoru Takahashi; Akihiko Kato; Yoshihide Fujigaki; Tatsuo Yamamoto; Akira Hishida

doi:10.2169/internalmedicine.41.1171

A patient with sarcoidosis presenting with acute renal failure: Implication for granulomatous interstitial nephritis and hypercalcemia

Naro Ohashi, Katsuhiko Yonemura, Manae Hirano, Satoru Takahashi, Akihiko Kato, Yoshihide Fujigaki, Tatsuo Yamamoto, Akira Hishida

Hamamatsu University School of Medicine

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

A woman was admitted for acute renal failure and erythematous lesions. She was diagnosed with sarcoidosis after analysis of biopsy specimens revealed noncaseating epithelioid granulomas, elevated serum angiotensin-converting enzyme levels, and bilateral hilar lymphadenopathy. Serum concentrations of ionized calcium and 1, 25-dihydroxyvitamin D₃ [1, 25-(OH)₂D₃] were extremely high. Serum intact osteocalcin concentration and urinary deoxypyridinoline excretion were within reference ranges. Treatment with prednisolone induced a prompt improvement with normalization of serum concentrations of ionized calcium and 1, 25-(OH)₂D₃. Serum intact osteocalcin concentration was markedly suppressed and urinary deoxypyridinoline excretion increased. It is possible suppressed bone resorption may be associated with overproduction of 1, 25-(OH)₂D₃.

Original language	English
Pages (from-to)	1171-1174
Number of pages	4
Journal	Internal Medicine
Volume	41
Issue number	12
DOIs	https://doi.org/10.2169/internalmedicine.41.1171
State	Published - 1 Dec 2002
Externally published	Yes

Keywords

Bone metabolism
Calcitriol

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10.2169/internalmedicine.41.1171

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title = "A patient with sarcoidosis presenting with acute renal failure: Implication for granulomatous interstitial nephritis and hypercalcemia",

abstract = "A woman was admitted for acute renal failure and erythematous lesions. She was diagnosed with sarcoidosis after analysis of biopsy specimens revealed noncaseating epithelioid granulomas, elevated serum angiotensin-converting enzyme levels, and bilateral hilar lymphadenopathy. Serum concentrations of ionized calcium and 1, 25-dihydroxyvitamin D3 [1, 25-(OH)2D3] were extremely high. Serum intact osteocalcin concentration and urinary deoxypyridinoline excretion were within reference ranges. Treatment with prednisolone induced a prompt improvement with normalization of serum concentrations of ionized calcium and 1, 25-(OH)2D3. Serum intact osteocalcin concentration was markedly suppressed and urinary deoxypyridinoline excretion increased. It is possible suppressed bone resorption may be associated with overproduction of 1, 25-(OH)2D3.",

keywords = "Bone metabolism, Calcitriol",

author = "Naro Ohashi and Katsuhiko Yonemura and Manae Hirano and Satoru Takahashi and Akihiko Kato and Yoshihide Fujigaki and Tatsuo Yamamoto and Akira Hishida",

year = "2002",

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doi = "10.2169/internalmedicine.41.1171",

language = "英語",

volume = "41",

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TY - JOUR

T1 - A patient with sarcoidosis presenting with acute renal failure

T2 - Implication for granulomatous interstitial nephritis and hypercalcemia

AU - Ohashi, Naro

AU - Yonemura, Katsuhiko

AU - Hirano, Manae

AU - Takahashi, Satoru

AU - Kato, Akihiko

AU - Fujigaki, Yoshihide

AU - Yamamoto, Tatsuo

AU - Hishida, Akira

PY - 2002/12/1

Y1 - 2002/12/1

N2 - A woman was admitted for acute renal failure and erythematous lesions. She was diagnosed with sarcoidosis after analysis of biopsy specimens revealed noncaseating epithelioid granulomas, elevated serum angiotensin-converting enzyme levels, and bilateral hilar lymphadenopathy. Serum concentrations of ionized calcium and 1, 25-dihydroxyvitamin D3 [1, 25-(OH)2D3] were extremely high. Serum intact osteocalcin concentration and urinary deoxypyridinoline excretion were within reference ranges. Treatment with prednisolone induced a prompt improvement with normalization of serum concentrations of ionized calcium and 1, 25-(OH)2D3. Serum intact osteocalcin concentration was markedly suppressed and urinary deoxypyridinoline excretion increased. It is possible suppressed bone resorption may be associated with overproduction of 1, 25-(OH)2D3.

AB - A woman was admitted for acute renal failure and erythematous lesions. She was diagnosed with sarcoidosis after analysis of biopsy specimens revealed noncaseating epithelioid granulomas, elevated serum angiotensin-converting enzyme levels, and bilateral hilar lymphadenopathy. Serum concentrations of ionized calcium and 1, 25-dihydroxyvitamin D3 [1, 25-(OH)2D3] were extremely high. Serum intact osteocalcin concentration and urinary deoxypyridinoline excretion were within reference ranges. Treatment with prednisolone induced a prompt improvement with normalization of serum concentrations of ionized calcium and 1, 25-(OH)2D3. Serum intact osteocalcin concentration was markedly suppressed and urinary deoxypyridinoline excretion increased. It is possible suppressed bone resorption may be associated with overproduction of 1, 25-(OH)2D3.

KW - Bone metabolism

KW - Calcitriol

UR - https://www.scopus.com/pages/publications/12244281481

U2 - 10.2169/internalmedicine.41.1171

DO - 10.2169/internalmedicine.41.1171

M3 - 記事

C2 - 12521209

AN - SCOPUS:12244281481

SN - 0918-2918

VL - 41

SP - 1171

EP - 1174

JO - Internal Medicine

JF - Internal Medicine

IS - 12

ER -

A patient with sarcoidosis presenting with acute renal failure: Implication for granulomatous interstitial nephritis and hypercalcemia

Abstract

Keywords

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