TY - JOUR
T1 - A new oxidative sensing and regulation pathway mediated by the MgrA homologue SarZ in Staphylococcus aureus
AU - Chen, Peng R.
AU - Nishida, Satoshi
AU - Poor, Catherine B.
AU - Cheng, Alice
AU - Bae, Taeok
AU - Kuechenmeister, Lisa
AU - Dunman, Paul M.
AU - Missiakas, Dominique
AU - He, Chuan
PY - 2009/1
Y1 - 2009/1
N2 - Oxidative stress serves as an important host/environmental signal that triggers a wide range of responses from the human pathogen Staphylococcus aureus. Among these, a thiol-based oxidation sensing pathway through a global regulator MgrA controls the virulence and antibiotic resistance of the bacterium. Herein, we report a new thiol-based oxidation sensing and regulation system that is mediated through a parallel global regulator SarZ. SarZ is a functional homologue of MgrA and is shown to affect the expression of ∼87 genes in S. aureus. It uses a key Cys residue, Cys-13, to sense oxidative stress and to co-ordinate the expression of genes involved in metabolic switching, antibiotic resistance, peroxide stress defence, virulence, and cell wall properties. The discovery of this SarZ-mediated regulation, mostly independent from the MgrA-based regulation, fills a missing gap of oxidation sensing and response in S. aureus.
AB - Oxidative stress serves as an important host/environmental signal that triggers a wide range of responses from the human pathogen Staphylococcus aureus. Among these, a thiol-based oxidation sensing pathway through a global regulator MgrA controls the virulence and antibiotic resistance of the bacterium. Herein, we report a new thiol-based oxidation sensing and regulation system that is mediated through a parallel global regulator SarZ. SarZ is a functional homologue of MgrA and is shown to affect the expression of ∼87 genes in S. aureus. It uses a key Cys residue, Cys-13, to sense oxidative stress and to co-ordinate the expression of genes involved in metabolic switching, antibiotic resistance, peroxide stress defence, virulence, and cell wall properties. The discovery of this SarZ-mediated regulation, mostly independent from the MgrA-based regulation, fills a missing gap of oxidation sensing and response in S. aureus.
UR - http://www.scopus.com/inward/record.url?scp=58149105545&partnerID=8YFLogxK
U2 - 10.1111/j.1365-2958.2008.06518.x
DO - 10.1111/j.1365-2958.2008.06518.x
M3 - 記事
C2 - 19007410
AN - SCOPUS:58149105545
SN - 0950-382X
VL - 71
SP - 198
EP - 211
JO - Molecular Microbiology
JF - Molecular Microbiology
IS - 1
ER -