A linkage map of the rat genome derived from three F2 crosses

Marie Thérèse Bihoreau; Dominique Gauguier; Norihiro Kato; Gina Hyne; Klaus Lindpaintner; John P. Rapp; Michael R. James; G. Mark Lathrop

doi:10.1101/gr.7.5.434

A linkage map of the rat genome derived from three F₂ crosses

Marie Thérèse Bihoreau
, Dominique Gauguier
, Norihiro Kato
, Gina Hyne
, Klaus Lindpaintner
, John P. Rapp
, Michael R. James
, G. Mark Lathrop

University of Oxford
Brigham and Women’s Hospital
University of Toledo

Research output: Contribution to journal › Article › peer-review

149 Scopus citations

Abstract

We report the construction of a dense linkage map of the rat genome integrating 767 simple sequence length polymorphism markers, combined over three crosses with high rates of polymorphism. F₂ populations from WKY x S (n = 159), BN x S (n = 91), and BN x GK (n = 139) were selected and genotyped for combinations of microsatellite markers. The loci define 21 linkage groups corresponding to the 20 rat autosomal chromosomes and the X chromosome. The map spans a genetic length of 1998 cM. This combined linkage map should facilitate the advancement of genetic studies for a wide variety of rat models characterized for complex phenotypes.

Original language	English
Pages (from-to)	434-440
Number of pages	7
Journal	Genome Research
Volume	7
Issue number	5
DOIs	https://doi.org/10.1101/gr.7.5.434
State	Published - May 1997
Externally published	Yes

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title = "A linkage map of the rat genome derived from three F2 crosses",

abstract = "We report the construction of a dense linkage map of the rat genome integrating 767 simple sequence length polymorphism markers, combined over three crosses with high rates of polymorphism. F2 populations from WKY x S (n = 159), BN x S (n = 91), and BN x GK (n = 139) were selected and genotyped for combinations of microsatellite markers. The loci define 21 linkage groups corresponding to the 20 rat autosomal chromosomes and the X chromosome. The map spans a genetic length of 1998 cM. This combined linkage map should facilitate the advancement of genetic studies for a wide variety of rat models characterized for complex phenotypes.",

author = "Bihoreau, \{Marie Th{\'e}r{\`e}se\} and Dominique Gauguier and Norihiro Kato and Gina Hyne and Klaus Lindpaintner and Rapp, \{John P.\} and James, \{Michael R.\} and Lathrop, \{G. Mark\}",

year = "1997",

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doi = "10.1101/gr.7.5.434",

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T1 - A linkage map of the rat genome derived from three F2 crosses

AU - Bihoreau, Marie Thérèse

AU - Gauguier, Dominique

AU - Kato, Norihiro

AU - Hyne, Gina

AU - Lindpaintner, Klaus

AU - Rapp, John P.

AU - James, Michael R.

AU - Lathrop, G. Mark

PY - 1997/5

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N2 - We report the construction of a dense linkage map of the rat genome integrating 767 simple sequence length polymorphism markers, combined over three crosses with high rates of polymorphism. F2 populations from WKY x S (n = 159), BN x S (n = 91), and BN x GK (n = 139) were selected and genotyped for combinations of microsatellite markers. The loci define 21 linkage groups corresponding to the 20 rat autosomal chromosomes and the X chromosome. The map spans a genetic length of 1998 cM. This combined linkage map should facilitate the advancement of genetic studies for a wide variety of rat models characterized for complex phenotypes.

AB - We report the construction of a dense linkage map of the rat genome integrating 767 simple sequence length polymorphism markers, combined over three crosses with high rates of polymorphism. F2 populations from WKY x S (n = 159), BN x S (n = 91), and BN x GK (n = 139) were selected and genotyped for combinations of microsatellite markers. The loci define 21 linkage groups corresponding to the 20 rat autosomal chromosomes and the X chromosome. The map spans a genetic length of 1998 cM. This combined linkage map should facilitate the advancement of genetic studies for a wide variety of rat models characterized for complex phenotypes.

UR - https://www.scopus.com/pages/publications/0030957846

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EP - 440

JO - Genome Research

JF - Genome Research

IS - 5

ER -

A linkage map of the rat genome derived from three F₂ crosses

Abstract

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