A case of AA amyloidosis associated with rheumatoid arthritis effectively treated with Infliximab

Takeshi Kuroda; Yasuhiro Otaki; Hiroe Sato; Takeo Fujimura; Takeshi Nakatsue; Syuichi Murakami; Minoru Sakatsume; Masaaki Nakano; Fumitake Gejyo

doi:10.1007/s00296-008-0590-z

A case of AA amyloidosis associated with rheumatoid arthritis effectively treated with Infliximab

Takeshi Kuroda
, Yasuhiro Otaki
, Hiroe Sato
, Takeo Fujimura
, Takeshi Nakatsue
, Syuichi Murakami
, Minoru Sakatsume
, Masaaki Nakano
, Fumitake Gejyo

Niigata University

Research output: Contribution to journal › Article › peer-review

29 Scopus citations

Abstract

We report the case of a 55-year-old Japanese woman with reactive AA amyloidosis associated with rheumatoid arthritis, in which inflammatory disease was completely suppressed with infliximab. Nephrotic syndrome was observed and renal biopsy specimens revealed amyloidosis deposits. Treatment with infliximab normalized the serum amyloid A (SAA) protein level, and subsequently nephritic syndrome disappeared and her creatinine clearance improved. Serial gastrointestinal biopsy specimens showed marked lasting regression of amyloid deposits. Thus treatment with infliximab represents an important therapeutic strategy for AA amyloidosis associated with RA.

Original language	English
Pages (from-to)	1155-1159
Number of pages	5
Journal	Rheumatology International
Volume	28
Issue number	11
DOIs	https://doi.org/10.1007/s00296-008-0590-z
State	Published - Sep 2008
Externally published	Yes

Keywords

AA amyloidosis
Gastrointestinal amyloidosis
Infliximab
Renal function
Rheumatoid arthritis

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10.1007/s00296-008-0590-z

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abstract = "We report the case of a 55-year-old Japanese woman with reactive AA amyloidosis associated with rheumatoid arthritis, in which inflammatory disease was completely suppressed with infliximab. Nephrotic syndrome was observed and renal biopsy specimens revealed amyloidosis deposits. Treatment with infliximab normalized the serum amyloid A (SAA) protein level, and subsequently nephritic syndrome disappeared and her creatinine clearance improved. Serial gastrointestinal biopsy specimens showed marked lasting regression of amyloid deposits. Thus treatment with infliximab represents an important therapeutic strategy for AA amyloidosis associated with RA.",

keywords = "AA amyloidosis, Gastrointestinal amyloidosis, Infliximab, Renal function, Rheumatoid arthritis",

author = "Takeshi Kuroda and Yasuhiro Otaki and Hiroe Sato and Takeo Fujimura and Takeshi Nakatsue and Syuichi Murakami and Minoru Sakatsume and Masaaki Nakano and Fumitake Gejyo",

year = "2008",

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AU - Kuroda, Takeshi

AU - Otaki, Yasuhiro

AU - Sato, Hiroe

AU - Fujimura, Takeo

AU - Nakatsue, Takeshi

AU - Murakami, Syuichi

AU - Sakatsume, Minoru

AU - Nakano, Masaaki

AU - Gejyo, Fumitake

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Y1 - 2008/9

N2 - We report the case of a 55-year-old Japanese woman with reactive AA amyloidosis associated with rheumatoid arthritis, in which inflammatory disease was completely suppressed with infliximab. Nephrotic syndrome was observed and renal biopsy specimens revealed amyloidosis deposits. Treatment with infliximab normalized the serum amyloid A (SAA) protein level, and subsequently nephritic syndrome disappeared and her creatinine clearance improved. Serial gastrointestinal biopsy specimens showed marked lasting regression of amyloid deposits. Thus treatment with infliximab represents an important therapeutic strategy for AA amyloidosis associated with RA.

AB - We report the case of a 55-year-old Japanese woman with reactive AA amyloidosis associated with rheumatoid arthritis, in which inflammatory disease was completely suppressed with infliximab. Nephrotic syndrome was observed and renal biopsy specimens revealed amyloidosis deposits. Treatment with infliximab normalized the serum amyloid A (SAA) protein level, and subsequently nephritic syndrome disappeared and her creatinine clearance improved. Serial gastrointestinal biopsy specimens showed marked lasting regression of amyloid deposits. Thus treatment with infliximab represents an important therapeutic strategy for AA amyloidosis associated with RA.

KW - AA amyloidosis

KW - Gastrointestinal amyloidosis

KW - Infliximab

KW - Renal function

KW - Rheumatoid arthritis

UR - https://www.scopus.com/pages/publications/49649101284

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SP - 1155

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JO - Rheumatology International

JF - Rheumatology International

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ER -

A case of AA amyloidosis associated with rheumatoid arthritis effectively treated with Infliximab

Abstract

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