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External positions
教授, Teikyo University
Apr 2024 → …
Keywords
- Nuclear Receptor
- Vitamin D
Research Fields
- Bioorganic chemistry
- Structural organic chemistry and physical organic chemistry
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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SDG 3 Good Health and Well-being
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Collaborations and top research areas from the last five years
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C22- to C26,27-Fluoro-2-(3-hydroxypropyl)-19-norvitamin D3, Side-chain Fluorinated MART-10s Suppress IL-19 Secretion from Th17-stimulated Keratinocytes: Potent Therapeutic Effects on Psoriasis Models
Translated title of the contribution :C22- to C26,27-Fluoro-2-(3-hydroxypropyl)-19-norvitamin D3, Side-chain Fluorinated MART-10s Suppress IL-19 Secretion from Th17-stimulated Keratinocytes: Potent Therapeutic Effects on Psoriasis Models Research output: Contribution to journal › Article
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Comprehensive Synthesis of Side-Chain Fluorinated 2α-[2-(Tetrazol-2-yl)ethyl]-1α, 25-dihydroxyvitamin D3 Analogs and Preliminary Biological Activities
Kawagoe, F., Mototani, S., Okamoto, Y., Murata, S., Takeuchi, A., Yatsu, T., Yasuda, K., Akagi, Y., Fujishima, T., Miyata, Y., Saitoh, H., Sakaki, T. & Kittaka, A., 2026, In: Chemical and Pharmaceutical Bulletin. 74, 1, p. 103-118 16 p.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
Synthesis of 23,23-Difluoro-24-nor- and 24′,24′-Difluoro-24-Homovitamin D3 Analogues and Unexpected Structure-Activity Relationships
Translated title of the contribution :Synthesis of 23,23-Difluoro-24-nor- and 24′,24′-Difluoro-24-Homovitamin D3 Analogues and Unexpected Structure-Activity Relationships Research output: Contribution to journal › Article
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Side-Chain Fluorine Engineering of Vitamin D3 Derivatives for VDR-Silent SREBP Inhibitors
Kawagoe, F., Mototani, S., Yatsu, T., Takemoto, Y., Akagi, Y., Fujishima, T., Miyata, Y., Uesugi, M. & Kittaka, A., 20 Sep 2025, In: Chemical and Pharmaceutical Bulletin. 73, 9, p. 868-883 16 p.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
Design and concise synthesis of novel vitamin D analogues bearing a functionalized aromatic ring on the side chain
Fujishima, T., Komatsu, T., Takao, Y., Yonamine, W., Suenaga, T., Isono, H., Morikawa, M. & Takaguchi, K., 22 Feb 2019, In: Tetrahedron. 75, 8, p. 1098-1106 9 p.Research output: Contribution to journal › Article › peer-review
3 Scopus citations
Datasets
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Crystal structure of VDR LBD complexed to 2alpha-propyl-calcitriol
Hourai, S. (Contributor), Fujishima, T. (Contributor), Kittaka, A. (Contributor), Suhara, Y. (Contributor), Takayama, H. (Contributor), Rochel, N. (Contributor) & Moras, D. (Contributor), Protein Data Bank (PDB), 29 Aug 2006
DOI: 10.2210/pdb2HAM/pdb, https://www.wwpdb.org/pdb?id=pdb_00002ham
Dataset
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CCDC 162973: Experimental Crystal Structure Determination
Fujishima, T. (Creator), Zhaopeng, L. (Creator), Konno, K. (Creator), Nakagawa, K. (Creator), Okano, T. (Creator), Yamaguchi, K. (Creator) & Takayama, H. (Creator), Cambridge Crystallographic Data Centre, 2001
DOI: 10.5517/cc5gl6d, http://www.ccdc.cam.ac.uk/services/structure_request?id=doi:10.5517/cc5gl6d&sid=DataCite
Dataset
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Crystal structure of VDR LBD in complex with 2alpha(3-hydroxy-1-propyl) calcitriol
Hourai, S. (Contributor), Fujishima, T. (Contributor), Kittaka, A. (Contributor), Suhara, Y. (Contributor), Takayama, H. (Contributor), Rochel, N. (Contributor) & Moras, D. (Contributor), Protein Data Bank (PDB), 29 Aug 2006
DOI: 10.2210/pdb2HB7/pdb, https://www.wwpdb.org/pdb?id=pdb_00002hb7
Dataset
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Crystal structure of VDR LBD in complex with 2alpha-methyl calcitriol
Hourai, S. (Contributor), Fujishima, T. (Contributor), Kittaka, A. (Contributor), Suhara, Y. (Contributor), Takayama, H. (Contributor), Rochel, N. (Contributor) & Moras, D. (Contributor), Protein Data Bank (PDB), 29 Aug 2006
DOI: 10.2210/pdb2HB8/pdb, https://www.wwpdb.org/pdb?id=pdb_00002hb8
Dataset
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Crystal structure of VDR LBD in complex with 2 alpha-(3-hydroxy-1-propoxy) calcitriol
Hourai, S. (Contributor), Fujishima, T. (Contributor), Kittaka, A. (Contributor), Suhara, Y. (Contributor), Takayama, H. (Contributor), Rochel, N. (Contributor) & Moras, D. (Contributor), Protein Data Bank (PDB), 29 Aug 2006
DOI: 10.2210/pdb2HAR/pdb, https://www.wwpdb.org/pdb?id=pdb_00002har
Dataset